| |
|
| About us |
 |
About us |
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
|
 |
About us |
 |
|
After the momentous achievement of sequencing
the human genome, genome science is turning to projects such as the
expression profile analysis of genes and their products. The HiCEP
Center, established at the National Institute of Radiological Sciences
in November, 2003, focuses on entire transcripts (transcriptomes).
Our major interests are:
| 1) |
For each biological phenomenon, what transcripts
are expressed with what timing, and what are the regulation mechanisms |
| 2) |
To study the transcriptome itself |
For this purpose, we have developed a new gene
expression profiling method, High Coverage Expression Profiling (HiCEP).
HiCEP is based on a different principle from that of the DNA chip (microarray)
technique and does not require any sequence information for its analysis,
so it can be used even for organisms for which we have no cDNA sequence
information. Furthermore, its high sensitivity (it can detect even
a 20% difference in gene expression) and high coverage can overcome
most difficulties in gene expression profiling analysis using previous
methods. HiCEP produces enough data to allow us to comprehensively
identify genes related to biological phenomena of interest and to discover
the network of genes regulating expression.
The purpose of the HiCEP Group is to develop a sensitive, high coverage gene
expression analysis method and promote collaboration with other researchers.
HiCEP analysis is applicable in many areas and we have received many proposals
for collaboration.
Through close study of entire transcripts, we can learn about the complete expression
mechanism. Our aim is to contribute not just to basic research, but also to medical
care and environmental science. We plan to collect expression profile data about
many different species and make them public.
|
|
